Endocrine Abstracts

Clinical response to metformin is highly variable in type 2 diabetes (T2D) patients highlighting the need for identification of genetic components affecting the efficiency of metformin therapy. Aim of this study was to evaluate the role of systematically selected tagSNPs from genomic regions coding for six organic cation transporters implicated in transport of metformin with respect to the short-term efficiency. The study involved 102 drug naïve newly diagnosed T2D patien...